Depending on what you are coding, I would almost always recommend it.

Here are two very nice introduction tutorials to the Zend Framework which uses MVC (Quicktime is unfortunately required).
- http://mitchellhashimoto.com/zend-fr...tting-started/
- http://mitchellhashimoto.com/zend-fr.../zend-registry

And here also two nice video tutorials using Code Igniter (Flash required).
- http://codeigniter.com/tutorials/

And lastly: http://www.phppatterns.com/docs/desi...roller_and_php

Any questions, just shoot.