I would put it in a 'bootstrap loader' (just like your computer), a file that is executed once per execution of the script that sets up your script.

In actual fact, it doesn't really matter where you do 'set', as long as its before you call the 'get' for that specific object.

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mysql> SELECT * FROM `users` WHERE `users`.`clue` > 0;
Empty set (0.00 sec)