If you mean how hard would it to be to layout a site like that? Easy as pie. How hard would it be to do the graphics design for a site like that. Not as easy, depends on your knowledge of Illustrator/Photoshop and artistic ability to boot. The front page of that site is using pretty minimal graphics except for the large vector... the whole thing loads pretty slow for me though, when it loads at all. Probably all that Wordpress garbage.
-m