Yes,

Do not forget that some peoples in front of the screen don't have your mobility.
Accesskeys and tabindexes have been created for them because, sometimes, they can not use both the keyboard and the mouse in the same time.
Shortcuts for links have so been invented.

In fact, mani criticizes are made to accesskeys because:
- all browsers don't manage them by the same way (on IE, you have to press Alt+Shift+letter AND press enter).
- the combination is awful and with one arm, try to press Alt+Shift+M on an azerty keyboard

But it's a good way to don't exclude some peoples :)

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